6bzs
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Human ABCC6 NBD1 in Apo state== |
| - | + | <StructureSection load='6bzs' size='340' side='right' caption='[[6bzs]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bzr|6bzr]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [http://pdbe.org/6bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [http://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Generalized arterial calcification of infancy;Pseudoxanthoma elasticum. The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Thibodeau, P H]] | ||
| + | [[Category: Zheng, A]] | ||
| + | [[Category: Abcc6]] | ||
| + | [[Category: Apo state]] | ||
| + | [[Category: Atp-binding cassette transporter c6]] | ||
| + | [[Category: Nbd1]] | ||
| + | [[Category: Nucleotide binding domain 1]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 10:05, 5 September 2018
Human ABCC6 NBD1 in Apo state
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