6c8c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06== | |
| - | + | <StructureSection load='6c8c' size='340' side='right'caption='[[6c8c]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c8c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C8C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EQ7:8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one'>EQ7</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8c OCA], [http://pdbe.org/6c8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8c RCSB], [http://www.ebi.ac.uk/pdbsum/6c8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLK_MOUSE POLK_MOUSE]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).<ref>PMID:12432099</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Najeeb, J]] | ||
| + | [[Category: Zhou, P]] | ||
| + | [[Category: Dna damage tolerance]] | ||
| + | [[Category: Replication]] | ||
| + | [[Category: Rev1]] | ||
| + | [[Category: Translesion synthesis]] | ||
Revision as of 05:29, 12 June 2019
Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06
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