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2gic
From Proteopedia
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[[Image:2gic.gif|left|200px]] | [[Image:2gic.gif|left|200px]] | ||
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'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex''' | '''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex''' | ||
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[[Category: Wertz, G W.]] | [[Category: Wertz, G W.]] | ||
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
| - | [[Category: | + | [[Category: Negative strand virus]] |
| - | [[Category: | + | [[Category: Nucleocapsid]] |
| - | [[Category: | + | [[Category: Protein-rna complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:08:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:08, 4 May 2008
Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex
Overview
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.
About this Structure
2GIC is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.
Reference
Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022 Page seeded by OCA on Sun May 4 05:08:24 2008
