2giu

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[[Image:2giu.gif|left|200px]]
[[Image:2giu.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2giu |SIZE=350|CAPTION= <scene name='initialview01'>2giu</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2giu", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FBR:(9AS)-4-BROMO-9A-BUTYL-7-HYDROXY-1,2,9,9A-TETRAHYDRO-3H-FLUOREN-3-ONE'>FBR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ESR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2giu| PDB=2giu | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giu OCA], [http://www.ebi.ac.uk/pdbsum/2giu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2giu RCSB]</span>
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}}
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'''Human estrogen receptor beta ligand-binding domain in complex with compound 45'''
'''Human estrogen receptor beta ligand-binding domain in complex with compound 45'''
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[[Category: Fitzgerald, P M.D.]]
[[Category: Fitzgerald, P M.D.]]
[[Category: Sharma, N.]]
[[Category: Sharma, N.]]
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[[Category: agonist]]
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[[Category: Agonist]]
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[[Category: er-beta]]
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[[Category: Er-beta]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:16 2008''
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Revision as of 02:09, 4 May 2008

Image:2giu.gif

Template:STRUCTURE 2giu

Human estrogen receptor beta ligand-binding domain in complex with compound 45


Overview

Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.

About this Structure

2GIU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands., Wilkening RR, Ratcliffe RW, Tynebor EC, Wildonger KJ, Fried AK, Hammond ML, Mosley RT, Fitzgerald PM, Sharma N, McKeever BM, Nilsson S, Carlquist M, Thorsell A, Locco L, Katz R, Frisch K, Birzin ET, Wilkinson HA, Mitra S, Cai S, Hayes EC, Schaeffer JM, Rohrer SP, Bioorg Med Chem Lett. 2006 Jul 1;16(13):3489-94. Epub 2006 May 2. PMID:16632357 Page seeded by OCA on Sun May 4 05:09:17 2008

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OCA

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