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6c2g

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Current revision (14:54, 4 October 2023) (edit) (undo)
 
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==Human triosephosphate isomerase mutant V231M==
==Human triosephosphate isomerase mutant V231M==
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<StructureSection load='6c2g' size='340' side='right' caption='[[6c2g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='6c2g' size='340' side='right'caption='[[6c2g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c2g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C2G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C2G FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPI1, TPI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c2g OCA], [https://pdbe.org/6c2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c2g RCSB], [https://www.ebi.ac.uk/pdbsum/6c2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c2g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c2g OCA], [http://pdbe.org/6c2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c2g RCSB], [http://www.ebi.ac.uk/pdbsum/6c2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c2g ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[http://omim.org/entry/190450 190450]]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
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[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
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== Function ==
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[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c2g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c2g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Triose-phosphate isomerase]]
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[[Category: Large Structures]]
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[[Category: Enriquez, F S]]
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[[Category: Enriquez FS]]
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[[Category: Torres, L A]]
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[[Category: Torres LA]]
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[[Category: Isomerase]]
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Current revision

Human triosephosphate isomerase mutant V231M

PDB ID 6c2g

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