2gjk

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[[Image:2gjk.gif|left|200px]]
[[Image:2gjk.gif|left|200px]]
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{{Structure
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|PDB= 2gjk |SIZE=350|CAPTION= <scene name='initialview01'>2gjk</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2gjk", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_2gjk| PDB=2gjk | SCENE= }}
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|RELATEDENTRY=[[2gk6|2GK6]], [[2gk7|2GK7]], [[2gk8|2GK8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjk OCA], [http://www.ebi.ac.uk/pdbsum/2gjk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gjk RCSB]</span>
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'''Structural and functional insights into the human Upf1 helicase core'''
'''Structural and functional insights into the human Upf1 helicase core'''
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[[Category: Parker, R.]]
[[Category: Parker, R.]]
[[Category: Song, H.]]
[[Category: Song, H.]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: hupf1]]
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[[Category: Hupf1]]
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[[Category: nmd]]
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[[Category: Nmd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:10:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:30 2008''
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Revision as of 02:10, 4 May 2008

Image:2gjk.gif

Template:STRUCTURE 2gjk

Structural and functional insights into the human Upf1 helicase core


Overview

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway that recognizes and degrades aberrant mRNAs containing premature stop codons. A critical protein in NMD is Upf1p, which belongs to the helicase super family 1 (SF1), and is thought to utilize the energy of ATP hydrolysis to promote transitions in the structure of RNA or RNA-protein complexes. The crystal structure of the catalytic core of human Upf1p determined in three states (phosphate-, AMPPNP- and ADP-bound forms) reveals an overall structure containing two RecA-like domains with two additional domains protruding from the N-terminal RecA-like domain. Structural comparison combined with mutational analysis identifies a likely single-stranded RNA (ssRNA)-binding channel, and a cycle of conformational change coupled to ATP binding and hydrolysis. These conformational changes alter the likely ssRNA-binding channel in a manner that can explain how ATP binding destabilizes ssRNA binding to Upf1p.

About this Structure

2GJK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into the human Upf1 helicase core., Cheng Z, Muhlrad D, Lim MK, Parker R, Song H, EMBO J. 2007 Jan 10;26(1):253-64. Epub 2006 Dec 7. PMID:17159905 Page seeded by OCA on Sun May 4 05:10:52 2008

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