2gmi

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[[Image:2gmi.jpg|left|200px]]
[[Image:2gmi.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2gmi |SIZE=350|CAPTION= <scene name='initialview01'>2gmi</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2gmi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= UBC13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), MMS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2gmi| PDB=2gmi | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gmi OCA], [http://www.ebi.ac.uk/pdbsum/2gmi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gmi RCSB]</span>
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}}
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'''Mms2/Ubc13~Ubiquitin'''
'''Mms2/Ubc13~Ubiquitin'''
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[[Category: Pickart, C M.]]
[[Category: Pickart, C M.]]
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
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[[Category: e2]]
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[[Category: E2]]
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[[Category: mms2]]
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[[Category: Mms2]]
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[[Category: ubc13]]
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[[Category: Ubc13]]
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[[Category: ubc13 ubiquitin covalent complex,]]
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[[Category: Ubc13 ubiquitin covalent complex]]
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[[Category: ubiquitin]]
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[[Category: Ubiquitin]]
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[[Category: uev]]
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[[Category: Uev]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:16:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:40 2008''
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Revision as of 02:16, 4 May 2008

Image:2gmi.jpg

Template:STRUCTURE 2gmi

Mms2/Ubc13~Ubiquitin


Overview

Lys63-linked polyubiquitin chains participate in nonproteolytic signaling pathways, including regulation of DNA damage tolerance and NF-kappaB activation. E2 enzymes bound to ubiquitin E2 variants (UEV) are vital in these pathways, synthesizing Lys63-linked polyubiquitin chains, but how these complexes achieve specificity for a particular lysine linkage has been unclear. We have determined the crystal structure of an Mms2-Ubc13-ubiquitin (UEV-E2-Ub) covalent intermediate with donor ubiquitin linked to the active site residue of Ubc13. In the structure, the unexpected binding of a donor ubiquitin of one Mms2-Ubc13-Ub complex to the acceptor-binding site of Mms2-Ubc13 in an adjacent complex allows us to visualize at atomic resolution the molecular determinants of acceptor-ubiquitin binding. The structure reveals the key role of Mms2 in allowing selective insertion of Lys63 into the Ubc13 active site and suggests a molecular model for polyubiquitin chain elongation.

About this Structure

2GMI is a Protein complex structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation., Eddins MJ, Carlile CM, Gomez KM, Pickart CM, Wolberger C, Nat Struct Mol Biol. 2006 Oct;13(10):915-20. Epub 2006 Sep 17. PMID:16980971 Page seeded by OCA on Sun May 4 05:16:20 2008

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