2gmv

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[[Image:2gmv.gif|left|200px]]
[[Image:2gmv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gmv |SIZE=350|CAPTION= <scene name='initialview01'>2gmv</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2gmv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene>, <scene name='pdbligand=UN8:N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE'>UN8</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PCK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gmv| PDB=2gmv | SCENE= }}
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|RELATEDENTRY=[[1khb|1KHB]], [[1nhx|1NHX]], [[1m51|1M51]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gmv OCA], [http://www.ebi.ac.uk/pdbsum/2gmv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gmv RCSB]</span>
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}}
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'''PEPCK complex with a GTP-competitive inhibitor'''
'''PEPCK complex with a GTP-competitive inhibitor'''
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C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase., Pietranico SL, Foley LH, Huby N, Yun W, Dunten P, Vermeulen J, Wang P, Toth K, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3835-9. Epub 2007 May 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17532214 17532214]
C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase., Pietranico SL, Foley LH, Huby N, Yun W, Dunten P, Vermeulen J, Wang P, Toth K, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3835-9. Epub 2007 May 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17532214 17532214]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Dunten, P.]]
[[Category: Dunten, P.]]
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[[Category: gluconeogenesis]]
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[[Category: Gluconeogenesis]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: xanthine]]
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[[Category: Xanthine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:17:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:47 2008''
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Revision as of 02:17, 4 May 2008

Image:2gmv.gif

Template:STRUCTURE 2gmv

PEPCK complex with a GTP-competitive inhibitor


Contents

Overview

New modifications on the C-8 4-aminobenzyl unit of the previously reported 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most active compound reported here is the 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with an IC(50) of 0.29+/-0.08 microM. An X-ray analysis of a heteroaromatic sulfonamide is presented showing a new pi-pi interaction.

Disease

Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[261680]

About this Structure

2GMV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase., Pietranico SL, Foley LH, Huby N, Yun W, Dunten P, Vermeulen J, Wang P, Toth K, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3835-9. Epub 2007 May 22. PMID:17532214 Page seeded by OCA on Sun May 4 05:17:20 2008

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OCA

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