CD44

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'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref>
'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref>
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*<scene name='52/523368/Cv/3'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref>
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*<scene name='52/523368/Cv/4'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref>
== Relevance ==
== Relevance ==

Revision as of 13:52, 10 February 2019

Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code 2jcq)

Drag the structure with the mouse to rotate

3D structures of CD44

Updated on 10-February-2019

1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk - mCD44 hyaluronan-binding domain + inhibitor
5bzt, 5bzs, 5bzr, 5bzq, 5bzp, 5bzo, 5bzn, 5bzm, 5bzl, 5bzj, 5bzi, 5bzh, 5bzg, 5bzf, 5bze - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide

References

  1. ↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532
  2. ↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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