2go5

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[[Image:2go5.gif|left|200px]]
[[Image:2go5.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2go5", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_2go5| PDB=2go5 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go5 OCA], [http://www.ebi.ac.uk/pdbsum/2go5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2go5 RCSB]</span>
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'''Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex'''
'''Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex'''
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[[Category: Schlenker, O.]]
[[Category: Schlenker, O.]]
[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: sr]]
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[[Category: Sr]]
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[[Category: srp]]
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[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:19:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:19:19 2008''
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Revision as of 02:20, 4 May 2008

Image:2go5.gif

Template:STRUCTURE 2go5

Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex


Overview

Signal sequences of secretory and membrane proteins are recognized by the signal recognition particle (SRP) as they emerge from the ribosome. This results in their targeting to the membrane by docking with the SRP receptor, which facilitates transfer of the ribosome to the translocon. Here, we present the 8 angstrom cryo-electron microscopy structure of a "docking complex" consisting of a SRP-bound 80S ribosome and the SRP receptor. Interaction of the SRP receptor with both SRP and the ribosome rearranged the S domain of SRP such that a ribosomal binding site for the translocon, the L23e/L35 site, became exposed, whereas Alu domain-mediated elongation arrest persisted.

About this Structure

2GO5 is a Protein complex structure of sequences from Canis sp., Homo sapiens, Mus musculus and Triticum sp.. Full crystallographic information is available from OCA.

Reference

Signal recognition particle receptor exposes the ribosomal translocon binding site., Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R, Science. 2006 May 5;312(5774):745-7. PMID:16675701 Page seeded by OCA on Sun May 4 05:19:57 2008

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