2gop
From Proteopedia
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[[Image:2gop.gif|left|200px]] | [[Image:2gop.gif|left|200px]] | ||
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'''The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology''' | '''The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology''' | ||
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[[Category: Tamura, N.]] | [[Category: Tamura, N.]] | ||
[[Category: Tamura, T.]] | [[Category: Tamura, T.]] | ||
| - | [[Category: | + | [[Category: Beta propeller]] |
| - | [[Category: | + | [[Category: Open velcro]] |
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Revision as of 02:20, 4 May 2008
The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology
Overview
In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides by compartmentalized proteases such as the proteasome complex. Accordingly, a variety of downstream proteases have evolved to further hydrolyze these peptides to the level of free amino acids. In the search for such downstream proteases, a high-molecular-weight protease complex called trilobed protease (TLP) was recently discovered in the archaeon Pyroccocus furiosus. The crystal structure of the N-terminal beta-propeller domain of the trilobed protease at 2 A resolution shows that the trilobed protease utilizes this accessory domain to control substrate access to the active site. Modelling of the intact TLP monomer suggests that this protease has an additional side entrance to its active site as in the DPP-IV or tricorn protease complexes.
About this Structure
2GOP is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.
Reference
The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology., Bosch J, Tamura T, Tamura N, Baumeister W, Essen LO, Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):179-87. Epub 2007, Jan 16. PMID:17242511 Page seeded by OCA on Sun May 4 05:20:46 2008
