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2gox

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[[Image:2gox.jpg|left|200px]]
[[Image:2gox.jpg|left|200px]]
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{{Structure
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|GENE= C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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{{STRUCTURE_2gox| PDB=2gox | SCENE= }}
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|RELATEDENTRY=[[2gom|2GOM]], [[2noj|2NOJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gox OCA], [http://www.ebi.ac.uk/pdbsum/2gox PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gox RCSB]</span>
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'''Crystal structure of Efb-C / C3d Complex'''
'''Crystal structure of Efb-C / C3d Complex'''
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[[Category: Geisbrecht, B V.]]
[[Category: Geisbrecht, B V.]]
[[Category: Hammel, M.]]
[[Category: Hammel, M.]]
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[[Category: cell adhesion/toxin complex]]
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[[Category: Cell adhesion/toxin complex]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:21:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:19:33 2008''
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Revision as of 02:21, 4 May 2008

Image:2gox.jpg

Template:STRUCTURE 2gox

Crystal structure of Efb-C / C3d Complex


Contents

Overview

To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.

Disease

Known disease associated with this structure: C3 deficiency OMIM:[120700], Macular degeneration, age-related, 9 OMIM:[120700]

About this Structure

2GOX is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618 Page seeded by OCA on Sun May 4 05:21:04 2008

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