2gph

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[[Image:2gph.gif|left|200px]]
[[Image:2gph.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gph |SIZE=350|CAPTION= <scene name='initialview01'>2gph</scene>, resolution 1.900&Aring;
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The line below this paragraph, containing "STRUCTURE_2gph", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Erk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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{{STRUCTURE_2gph| PDB=2gph | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gph OCA], [http://www.ebi.ac.uk/pdbsum/2gph PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gph RCSB]</span>
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'''Docking motif interactions in the MAP kinase ERK2'''
'''Docking motif interactions in the MAP kinase ERK2'''
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[[Category: Sun, L.]]
[[Category: Sun, L.]]
[[Category: Zhou, T.]]
[[Category: Zhou, T.]]
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[[Category: allostery]]
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[[Category: Allostery]]
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[[Category: cd-site]]
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[[Category: Cd-site]]
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[[Category: d-motif]]
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[[Category: D-motif]]
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[[Category: docking interaction]]
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[[Category: Docking interaction]]
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[[Category: erk2]]
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[[Category: Erk2]]
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[[Category: phosphatase-derived peptide]]
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[[Category: Phosphatase-derived peptide]]
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[[Category: processing conformation]]
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[[Category: Processing conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:22:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:19:47 2008''
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Revision as of 02:22, 4 May 2008

Image:2gph.gif

Template:STRUCTURE 2gph

Docking motif interactions in the MAP kinase ERK2


Overview

MAP kinases bind activating kinases, phosphatases, and substrates through docking interactions. Here, we report a 1.9 A crystallographic analysis of inactive ERK2 bound to a "D motif" docking peptide (pepHePTP) derived from hematopoietic tyrosine phosphatase, a negative regulator of ERK2. In this complex, the complete D motif interaction defined by mutagenic analysis is observed, including extensive electrostatic interactions with the "CD" site of the kinase. Large conformational changes occur in the activation loop where the dual phosphorylation sites, which are buried in the inactive form of ERK2, become exposed to solvent in the complex. Similar conformational changes occur in a complex between ERK2 and a MEK2 (MAP/ERK kinase-2)-derived D motif peptide (pepMEK2). D motif peptides are known to bind homologous loci in the MAP kinases p38alpha and JNK1, also inducing conformational changes in these enzymes. However, the binding interactions and conformational changes are unique to each, thus contributing to specificity among MAP kinases.

About this Structure

2GPH is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Docking interactions induce exposure of activation loop in the MAP kinase ERK2., Zhou T, Sun L, Humphreys J, Goldsmith EJ, Structure. 2006 Jun;14(6):1011-9. PMID:16765894 Page seeded by OCA on Sun May 4 05:22:09 2008

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