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2gvf

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[[Image:2gvf.gif|left|200px]]
[[Image:2gvf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gvf |SIZE=350|CAPTION= <scene name='initialview01'>2gvf</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2gvf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NHN:(6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE'>NHN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2gvf| PDB=2gvf | SCENE= }}
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|RELATEDENTRY=[[1a1r|1A1R]], [[2fm2|2FM2]], [[1rgq|1RGQ]], [[2a4g|2A4G]], [[2a4r|2A4R]], [[2a4q|2A4Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gvf OCA], [http://www.ebi.ac.uk/pdbsum/2gvf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gvf RCSB]</span>
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}}
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'''HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021'''
'''HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021'''
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[[Category: Prongay, A.]]
[[Category: Prongay, A.]]
[[Category: Venkatraman, S.]]
[[Category: Venkatraman, S.]]
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[[Category: hepatitis c]]
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[[Category: Hepatitis c]]
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[[Category: ketoamide inhibitor]]
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[[Category: Ketoamide inhibitor]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:35:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:10 2008''
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Revision as of 02:35, 4 May 2008

Image:2gvf.gif

Template:STRUCTURE 2gvf

HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021


Overview

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.

About this Structure

2GVF is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease., Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985 Page seeded by OCA on Sun May 4 05:35:08 2008

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OCA

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