Sandbox Reserved 1452

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== Relevance ==
== Relevance ==
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Uricase is an enzyme that catalyzes the conversion or uric acid to allantoin. Uric acid is
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an acidic waste product that your body passes through urine. It is a normal byproduct of the
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breakdown of foods that contain purines. Normally, the kidneys filter out uric acid from your
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blood; if too much builds up, it can lower the pH of your blood and urine and lead to a painful
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joint condition called gout and other complications. The reason I chose uricase is because it
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monitors the uric acid levels in our body. Interestingly, humans have naturally selected to
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terminate uricase. Because of the absence of uricase in humans, we may go through many
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complications caused by uric acid build up. Scientists are studying why natural selection would
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allow the accumulation of uric acid even though there are psychological complications of
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crystalized monosodium urate acutely causing liver and kidney damage or chronically causing
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gout.
== Structural highlights ==
== Structural highlights ==

Revision as of 19:51, 11 April 2018

This Sandbox is Reserved from Jan 22 through May 22, 2018 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, Missouri, USA. This reservation includes Sandbox Reserved 1446 through Sandbox Reserved 1455.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Uricase

Caption for this structure

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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