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Put basic info about uricase here

Function

It is an enzyme that converts uric acid to allantoin. Allantoin is much more soluble than uric acid, and passes harmlessly from the body. Unfortunately, during evolution, humans have lost the ability to produce uricase (also called urate oxidase).

Disease

Relevance

Uricase is an enzyme that catalyzes the conversion or uric acid to allantoin. Uric acid is an acidic waste product that your body passes through urine. It is a normal byproduct of the breakdown of foods that contain purines. Normally, the kidneys filter out uric acid from your blood; if too much builds up, it can lower the pH of your blood and urine and lead to a painful joint condition called gout and other complications. The reason I chose uricase is because it monitors the uric acid levels in our body. Interestingly, humans have naturally selected to terminate uricase. Because of the absence of uricase in humans, we may go through many complications caused by uric acid build up. Scientists are studying why natural selection would allow the accumulation of uric acid even though there are psychological complications of crystalized monosodium urate acutely causing liver and kidney damage or chronically causing gout.

Structural highlights

This is without a ligand. You can view uricase with a ligand