Acetyl-CoA synthetase
From Proteopedia
(Difference between revisions)
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== Structural Highlights == | == Structural Highlights == | ||
| - | *<scene name='49/492048/Cv/6'>CoA binding site</scene>. | + | *<scene name='49/492048/Cv/6'>CoA binding site</scene>. Water molecules shown as red spheres. |
*<scene name='49/492048/Cv/7'>AMP binding site</scene>. | *<scene name='49/492048/Cv/7'>AMP binding site</scene>. | ||
*<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref> | *<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref> | ||
Revision as of 13:37, 16 April 2018
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3D structures of acetyl-CoA synthetase
Updated on 16-April-2018
1pg3, 1pg4 – SeACS (mutant) + CoA + AMP – Salmonella enterica
2p20, 2p2m, 2p2q - StACS (mutant) + AMP – Salmonella typhimurium
2p2b, 2p2j - StACS (mutant) + CoA + AMP
2p2f, 5jrh - StACS + CoA + AMP
1ry2 – ACS + AMP - yeast
4u5y – ACS GNAT domain + SeACS C terminal (mutant) – Streptomyces lividans
5k85 - CnACS + APP + CoA - Cryptococcus neoformans
5k8f - CnACS + ATP + acetyl-AMP
5ifi - CnACS + APP
4xyl, 5hbr - KcACS + CoA - Korarchaeum cryptofilum
4xym - KcACS + AMPCP + CoA
4xz3 - KcACS + AMPPCP + CoA
4y8v, 4yb8, 4ybz - KcACS + ADP
4yaj - KcACS
4yak - KcACS + CoA + acetyl-CoA
References
- ↑ Jogl G, Tong L. Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry. 2004 Feb 17;43(6):1425-31. PMID:14769018 doi:10.1021/bi035911a
- ↑ Reger AS, Carney JM, Gulick AM. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 2007 Jun 5;46(22):6536-46. Epub 2007 May 12. PMID:17497934 doi:http://dx.doi.org/10.1021/bi6026506
