2gx9

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[[Image:2gx9.gif|left|200px]]
[[Image:2gx9.gif|left|200px]]
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{{Structure
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|PDB= 2gx9 |SIZE=350|CAPTION= <scene name='initialview01'>2gx9</scene>, resolution 2.100&Aring;
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The line below this paragraph, containing "STRUCTURE_2gx9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Segment 8 - NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11309 unidentified influenza virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2gx9| PDB=2gx9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gx9 OCA], [http://www.ebi.ac.uk/pdbsum/2gx9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gx9 RCSB]</span>
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'''X-ray strucutre of influenza virus NS1 effector domain'''
'''X-ray strucutre of influenza virus NS1 effector domain'''
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[[Category: Bornholdt, Z A.]]
[[Category: Bornholdt, Z A.]]
[[Category: Prasad, B V.]]
[[Category: Prasad, B V.]]
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[[Category: alpha-helix beta-crescent]]
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[[Category: Alpha-helix beta-crescent]]
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[[Category: effector domain]]
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[[Category: Effector domain]]
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[[Category: influenza]]
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[[Category: Influenza]]
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[[Category: ns1]]
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[[Category: Ns1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:38:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:49 2008''
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Revision as of 02:38, 4 May 2008

Image:2gx9.gif

Template:STRUCTURE 2gx9

X-ray strucutre of influenza virus NS1 effector domain


Overview

The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.

About this Structure

2GX9 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.

Reference

X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094 Page seeded by OCA on Sun May 4 05:38:36 2008

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OCA

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