2gy7

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[[Image:2gy7.gif|left|200px]]
[[Image:2gy7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gy7 |SIZE=350|CAPTION= <scene name='initialview01'>2gy7</scene>, resolution 3.700&Aring;
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The line below this paragraph, containing "STRUCTURE_2gy7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TEK, TIE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gy7| PDB=2gy7 | SCENE= }}
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|RELATEDENTRY=[[2gy5|2GY5]], [[1z3s|1Z3S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gy7 OCA], [http://www.ebi.ac.uk/pdbsum/2gy7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gy7 RCSB]</span>
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}}
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'''Angiopoietin-2/Tie2 Complex Crystal Structure'''
'''Angiopoietin-2/Tie2 Complex Crystal Structure'''
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[[Category: Barton, W A.]]
[[Category: Barton, W A.]]
[[Category: Nikolov, D B.]]
[[Category: Nikolov, D B.]]
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[[Category: receptor-ligand complex]]
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[[Category: Receptor-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:39:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:58 2008''
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Revision as of 02:39, 4 May 2008

Image:2gy7.gif

Template:STRUCTURE 2gy7

Angiopoietin-2/Tie2 Complex Crystal Structure


Overview

The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together with the three epidermal growth factor domains into a compact, arrowhead-shaped structure. Ang2 binds at the tip of the arrowhead utilizing a lock-and-key mode of ligand recognition-unique for a receptor kinase-where two complementary surfaces interact with each other with no domain rearrangements and little conformational change in either molecule. Ang2-Tie2 recognition is similar to antibody-protein antigen recognition, including the location of the ligand-binding site within the Ig fold. Analysis of the structures and structure-based mutagenesis provide insight into the mechanism of receptor activation and support the hypothesis that all angiopoietins interact with Tie2 in a structurally similar manner.

About this Structure

2GY7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex., Barton WA, Tzvetkova-Robev D, Miranda EP, Kolev MV, Rajashankar KR, Himanen JP, Nikolov DB, Nat Struct Mol Biol. 2006 Jun;13(6):524-32. Epub 2006 May 28. PMID:16732286 Page seeded by OCA on Sun May 4 05:39:09 2008

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