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2gzh

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[[Image:2gzh.gif|left|200px]]
[[Image:2gzh.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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|GENE= RAB11a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2gzh| PDB=2gzh | SCENE= }}
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|RELATEDENTRY=[[2gzd|2GZD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gzh OCA], [http://www.ebi.ac.uk/pdbsum/2gzh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gzh RCSB]</span>
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'''Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2'''
'''Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Khan, A R.]]
[[Category: Khan, A R.]]
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[[Category: a-helical coiled coil]]
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[[Category: A-helical coiled coil]]
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[[Category: ras-like g protein fold]]
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[[Category: Ras-like g protein fold]]
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Revision as of 02:41, 4 May 2008

Image:2gzh.gif

Template:STRUCTURE 2gzh

Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2


Overview

The small GTPase Rab11 regulates the recycling of endosomes to the plasma membrane via interactions with the Rab11 family of interacting proteins (FIPs). FIPs contain a highly conserved Rab binding domain (RBD) at their C termini whose structure is unknown. Here, we have determined the crystal structure of the RBD of FIP2 in complex with Rab11(GTP) by single wavelength anomalous diffraction methods. The overall structure is a heterotetramer with dyad symmetry, arranged as a Rab11-(FIP2)2-Rab11 complex. FIP2 forms a central alpha-helical coiled coil, with both helices contributing to the Rab11 binding patch on equivalent and opposite sides of the homodimer. Switch 1 of Rab11 is embedded between the two helices, while switch 2 remains flexible and is peripherally associated with the effector. The complex reveals the structural basis for Rab11 recognition by FIPs and suggests the molecular mechanisms underlying endocytic recycling pathways.

About this Structure

2GZH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of rab11 in complex with rab11 family interacting protein 2., Jagoe WN, Lindsay AJ, Read RJ, McCoy AJ, McCaffrey MW, Khan AR, Structure. 2006 Aug;14(8):1273-83. PMID:16905101 Page seeded by OCA on Sun May 4 05:41:12 2008

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