6d1t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6d1t" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6d1t is ON HOLD
+
==Complex of MBD1-MBD and methylated DNA==
-
 
+
<StructureSection load='6d1t' size='340' side='right' caption='[[6d1t]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
Authors: Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6d1t]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1T FirstGlance]. <br>
-
Description: Complex of MBD1-MBD and methylated DNA
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
-
[[Category: Arrowsmith, C.H]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1t OCA], [http://pdbe.org/6d1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1t RCSB], [http://www.ebi.ac.uk/pdbsum/6d1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1t ProSAT]</span></td></tr>
-
[[Category: Xu, C]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
 +
[[Category: Bountra, C]]
 +
[[Category: Edwards, A M]]
[[Category: Liu, K]]
[[Category: Liu, K]]
[[Category: Min, J]]
[[Category: Min, J]]
-
[[Category: Edwards, A.M]]
+
[[Category: Structural genomic]]
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
-
[[Category: Bountra, C]]
+
[[Category: Tempel, W]]
[[Category: Tempel, W]]
 +
[[Category: Xu, C]]
 +
[[Category: Dna binding protein-dna complex]]
 +
[[Category: Dna-methylation]]
 +
[[Category: Mbd]]
 +
[[Category: Sgc]]

Revision as of 06:19, 9 May 2018

Complex of MBD1-MBD and methylated DNA

6d1t, resolution 2.25Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6d1t"
Personal tools