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6g2d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution== | |
| - | + | <StructureSection load='6g2d' size='340' side='right' caption='[[6g2d]], [[Resolution|resolution]] 5.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g2d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2d OCA], [http://pdbe.org/6g2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2d RCSB], [http://www.ebi.ac.uk/pdbsum/6g2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2d ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chami, M]] | ||
| + | [[Category: Hagmann, A]] | ||
| + | [[Category: Hunkeler, M]] | ||
| + | [[Category: Maier, T]] | ||
| + | [[Category: Stahlberg, H]] | ||
| + | [[Category: Stuttfeld, E]] | ||
| + | [[Category: Biotin-dependent carboxylase]] | ||
| + | [[Category: Filament]] | ||
| + | [[Category: Helical]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Multienzyme]] | ||
Revision as of 07:43, 14 June 2018
Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution
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