This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5eg9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:25, 5 July 2023) (edit) (undo)
 
Line 1: Line 1:
==The cap binding site of influenza virus protein PB2 as a drug target==
==The cap binding site of influenza virus protein PB2 as a drug target==
-
<StructureSection load='5eg9' size='340' side='right' caption='[[5eg9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='5eg9' size='340' side='right'caption='[[5eg9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/I02a6 I02a6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG9 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Ck/HK/YU22/2002(H5N1)) Influenza A virus (A/Ck/HK/YU22/2002(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EG9 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[5eg8|5eg8]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284177 I02A6])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [https://pdbe.org/5eg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [https://www.ebi.ac.uk/pdbsum/5eg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg9 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [http://pdbe.org/5eg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg9 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
+
[https://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 20:
==See Also==
==See Also==
-
*[[RNA polymerase|RNA polymerase]]
+
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: I02a6]]
+
[[Category: Large Structures]]
-
[[Category: Li, K]]
+
[[Category: Li K]]
-
[[Category: Liu, Y]]
+
[[Category: Liu Y]]
-
[[Category: Luo, M]]
+
[[Category: Luo M]]
-
[[Category: Moura, T Rocha de]]
+
[[Category: Rocha de Moura T]]
-
[[Category: Severin, C]]
+
[[Category: Severin C]]
-
[[Category: Zheng, X]]
+
[[Category: Zheng X]]
-
[[Category: Pb2 cap]]
+
-
[[Category: Viral protein]]
+

Current revision

The cap binding site of influenza virus protein PB2 as a drug target

PDB ID 5eg9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5eg9"
Personal tools