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5eg9

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==The cap binding site of influenza virus protein PB2 as a drug target==
==The cap binding site of influenza virus protein PB2 as a drug target==
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<StructureSection load='5eg9' size='340' side='right' caption='[[5eg9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5eg9' size='340' side='right'caption='[[5eg9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/I02a6 I02a6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Ck/HK/YU22/2002(H5N1)) Influenza A virus (A/Ck/HK/YU22/2002(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EG9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[5eg8|5eg8]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284177 I02A6])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [https://pdbe.org/5eg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [https://www.ebi.ac.uk/pdbsum/5eg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [http://pdbe.org/5eg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
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[https://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: I02a6]]
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[[Category: Large Structures]]
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[[Category: Li, K]]
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[[Category: Li K]]
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[[Category: Liu, Y]]
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[[Category: Liu Y]]
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[[Category: Luo, M]]
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[[Category: Luo M]]
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[[Category: Moura, T Rocha de]]
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[[Category: Rocha de Moura T]]
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[[Category: Severin, C]]
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[[Category: Severin C]]
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[[Category: Zheng, X]]
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[[Category: Zheng X]]
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[[Category: Pb2 cap]]
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[[Category: Viral protein]]
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Current revision

The cap binding site of influenza virus protein PB2 as a drug target

PDB ID 5eg9

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