1xm9

From Proteopedia

(Difference between revisions)

Revision as of 10:07, 6 January 2021

Structure of the armadillo repeat domain of plakophilin 1

Structural highlights

1xm9 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	PKP1 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[PKP1_HUMAN] Defects in PKP1 are the cause of ectodermal dysplasia-skin fragility syndrome (EDSFS) [MIM:604536]; also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.

Function

[PKP1_HUMAN] Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.

Structure of the armadillo repeat domain of plakophilin 1.,Choi HJ, Weis WI J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Choi HJ, Weis WI. Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951 doi:10.1016/j.jmb.2004.11.048

1 Structural highlights
2 Disease
3 Function
4 Evolutionary Conservation
5 Publication Abstract from PubMed
6 See Also
7 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xm9"

@@ Line 1: / Line 1: @@
 ==Structure of the armadillo repeat domain of plakophilin 1==
-<StructureSection load='1xm9' size='340' side='right' caption='[[1xm9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='1xm9' size='340' side='right'caption='[[1xm9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1xm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XM9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1xm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XM9 FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PKP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm9 OCA], [http://pdbe.org/1xm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xm9 RCSB], [http://www.ebi.ac.uk/pdbsum/1xm9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm9 OCA], [http://pdbe.org/1xm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xm9 RCSB], [http://www.ebi.ac.uk/pdbsum/1xm9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm9 ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 30: / Line 30: @@
 </div>
 <div class="pdbe-citations 1xm9" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Armadillo repeats|Armadillo repeats]]
 == References ==
 <references/>
@@ Line 35: / Line 38: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Choi, H J]]
 [[Category: Weis, W I]]
 [[Category: Armadillo repeat]]
 [[Category: Cell adhesion]]

1xm9

From Proteopedia

Revision as of 10:07, 6 January 2021

Structure of the armadillo repeat domain of plakophilin 1

Structural highlights

Disease

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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