Sandbox GGC7

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Human Trypsin IV is a proteinase (1). Trypsins are mainly found in the pancreas and aid in food digestion; however, there are other trypsins that are present in the human brain and are homologous to those found in other animals such as mice (1). A lot of research is being conducted in this particular protein because of its association with mental health problems.

Function

It is mostly associated with disease and abnormal function in the brain. It is unclear if there is a normal function of this protein, but there is research suggesting it plays a role in neural development (1).It is associated with neurodegenerative diseases such as Alzheimer's, and possibly dementia (2). Trypsin IV is found in glial cells and astrocytes (2). It breaks down proteins in the brain and forms aggregates called amyloids (2). These sticky structures harden and form plaque (2).

Progressive accumulation of plaque in the brain is what causes Alzheimer's. There are inhibitors of this protein present in the brain, but it is able to defend against them because it is too big to fit into the active site of the inhibitor (2). A change in one of its residues is responsible for the immunity to its inhibitor. When Gly193 becomes Arginine, it can cause disease.

Disease

Relevance

Structural highlights

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