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Sandbox GGC12

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<scene name='78/781196/Disulfide_linkage_aandb/2'>Here you are able to get a clear view of the disulfide linkage between Helix A and Helix B. </scene>
<scene name='78/781196/Disulfide_linkage_aandb/2'>Here you are able to get a clear view of the disulfide linkage between Helix A and Helix B. </scene>
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There are water molecules throughout the IL-6 structure that form a network of hydrogen bonds that stabilize the molecule's structure.<ref>Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.</ref><scene name='78/781196/View_of_the_water_structure/1'>Here you are able to get a view of the water structure in the region between the D helix and the A-B loop of IL-6. </scene>
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There are water molecules throughout the IL-6 structure that form a network of hydrogen bonds that stabilize the molecule's structure.<ref>Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.</ref><scene name='78/781196/View_of_the_water_structure/2'>Here you are able to get a view of the water structure in the region between the D helix and the A-B loop of IL-6. </scene>
The water molecules are shown as red spheres. The A-B loop is shown in brown with a yellow disulfide linkage near F74 which is displayed in pink. The D helix is shown in black. Q175 is shown in green. R179 is shown in blue.<ref>Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.</ref>
The water molecules are shown as red spheres. The A-B loop is shown in brown with a yellow disulfide linkage near F74 which is displayed in pink. The D helix is shown in black. Q175 is shown in green. R179 is shown in blue.<ref>Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.</ref>

Revision as of 12:35, 23 April 2018

Structure: Human Interleukin-6

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
  4. ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
  5. ↑ Yoshizaki, Kazuyuki. "The Role of Interleukin-6 in Castleman Disease." Hematol Oncol Clin N Am.
  6. ↑ Yoshizaki, Kazuyuki. "The Role of Interleukin-6 in Castleman Disease." Hematol Oncol Clin N Am.
  7. ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
  8. ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
  9. ↑ Somers, William. "1.9 A? crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." The EMBO Journal.
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