This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Acyl-CoA dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 12: | Line 12: | ||
== Structural highlights == | == Structural highlights == | ||
| - | SCAD is a homodimer with a single FAD binding site. | + | SCAD is a homodimer with a single FAD binding site. <scene name='49/491924/Cv/12'>MCAD is a homotetramer</scene> with 4 FAD binding sites in the subunits interface and 4 binding sites for acyl-CoA substrate within each monomer. |
*One of the <scene name='49/491924/Cv/9'>FAD binding sites</scene> in homotetramer of rat ACDH. Water molecules are shown as red spheres. | *One of the <scene name='49/491924/Cv/9'>FAD binding sites</scene> in homotetramer of rat ACDH. Water molecules are shown as red spheres. | ||
*One of the <scene name='49/491924/Cv/11'>CoA binding sites</scene> in homotetramer of rat ACDH.<ref>PMID:11812788</ref> | *One of the <scene name='49/491924/Cv/11'>CoA binding sites</scene> in homotetramer of rat ACDH.<ref>PMID:11812788</ref> | ||
Revision as of 10:50, 20 December 2018
| |||||||||||
3D structures of acyl-CoA dehydrogenase
Updated on 20-December-2018
References
- ↑ Thorpe C, Kim JJ. Structure and mechanism of action of the acyl-CoA dehydrogenases. FASEB J. 1995 Jun;9(9):718-25. PMID:7601336
- ↑ Battaile KP, Molin-Case J, Paschke R, Wang M, Bennett D, Vockley J, Kim JJ. Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases. J Biol Chem. 2002 Apr 5;277(14):12200-7. Epub 2002 Jan 25. PMID:11812788 doi:10.1074/jbc.M111296200
