3BAJ is used in a lot of studies that have to do with allosteric activiation of human pancreatic alpha-amylase via chloride ions. It's primarily used as a anion substitution by using kinetic and structural experimentations. [1] or to the article describing Jmol [2].
Function
Alpha-amylase activity which allows for the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
Disease
No diseases found associated with this
Relevance
This is one type of major molecule that is used as an alternative anion which can induce some level of enzymatic activity despite very different atomic geometries, sizes, and polyatomic natures
Structural highlights
This is a view of the only found in 3BAJ
The ligand is composed of NO3
</StrcutureSection>
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Maurus R, Begum A, Williams LK, Fredriksen JR, Zhang R, Withers SG, Brayer GD
Biochemistry 47 3332-44 (2008)
