Acylaminoacyl peptidase
From Proteopedia
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AARE contains a <scene name='43/433643/Cv/6'>C-terminal hydrolase</scene> (in olive) and an <scene name='43/433643/Cv/7'>N-terminal β-propeller domain</scene> (in green). <scene name='43/433643/Cv/8'>Active site is S445, D524, H556</scene>. <ref>PMID:17350041</ref> The enzyme exists in an open state in which the oxyanion active site is accessible to the substrate and in a closed state where the active site is blocked. | AARE contains a <scene name='43/433643/Cv/6'>C-terminal hydrolase</scene> (in olive) and an <scene name='43/433643/Cv/7'>N-terminal β-propeller domain</scene> (in green). <scene name='43/433643/Cv/8'>Active site is S445, D524, H556</scene>. <ref>PMID:17350041</ref> The enzyme exists in an open state in which the oxyanion active site is accessible to the substrate and in a closed state where the active site is blocked. | ||
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| + | == 3D Structures of Acylaminoacyl peptidase == | ||
| + | [[Acylaminoacyl peptidase | ||
</StructureSection> | </StructureSection> | ||
__NOTOC__ | __NOTOC__ | ||
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[[4hxe]], [[4hxg]] – PhAARE - ''Pyrococcus horikoshii''<br /> | [[4hxe]], [[4hxg]] – PhAARE - ''Pyrococcus horikoshii''<br /> | ||
[[4hxf]] – PhAARE+ peptide chloromethyl ketone<br /> | [[4hxf]] – PhAARE+ peptide chloromethyl ketone<br /> | ||
| + | [[5l8s]] – AARE – ''Sporosarcina psychrophila''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:56, 27 February 2019
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3D Structures of Acylaminoacyl peptidase
Updated on 27-February-2019
3o4g, 3o4h, 3o4i, 3o4j, 2hu5, 2hu7, 2hu8, 1ve6 – ApAARE – Aeropyrum pernix
2qr5, 2qzp – ApAARE (mutant)
1ve7 – ApAARE+p-nitrophenyl phosphate
4re5, 4re6 – ApAARE+ inhibitor
3fnb – AARE – Streptococcus mutans
4hxe, 4hxg – PhAARE - Pyrococcus horikoshii
4hxf – PhAARE+ peptide chloromethyl ketone
5l8s – AARE – Sporosarcina psychrophila
References
- ↑ Harmat V, Domokos K, Menyhard DK, Pallo A, Szeltner Z, Szamosi I, Beke-Somfai T, Naray-Szabo G, Polgar L. Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase. J Biol Chem. 2010 Nov 16. PMID:21084296 doi:10.1074/jbc.M110.169862
- ↑ Kiss AL, Hornung B, Radi K, Gengeliczki Z, Sztaray B, Juhasz T, Szeltner Z, Harmat V, Polgar L. The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity. J Mol Biol. 2007 Apr 27;368(2):509-20. Epub 2007 Feb 20. PMID:17350041 doi:10.1016/j.jmb.2007.02.025
