Adaptin

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*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
 +
 +
==3D structures of adaptin==
 +
[[Adaptin 3D structures]]
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</StructureSection>
</StructureSection>
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**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
-
**[[1bw8]], [[1i31]] – rAP-2 + EGFR peptide<br />
 
-
**[[1bxx]] – rAP-2 + TGN38 peptide<br />
 
-
**[[1hes]] – rAP-2 + selectin peptide<br />
 
-
**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
 
**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
-
**[[2pr9]] – rAP-2 + GABA receptor peptide<br />
+
**[[1bw8]], [[1i31]] – rAP-2 C-terminal + EGFR peptide<br />
 +
**[[1bxx]] – rAP-2 C-terminal + TGN38 peptide<br />
 +
**[[1hes]] – rAP-2 C-terminal + selectin peptide<br />
 +
**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
 +
**[[2pr9]] – rAP-2 C-terminal + GABA receptor peptide<br />
 +
**[[5wrm]], [[5wrl]], [[5wrk]] – rAP-2 C-terminal + insulin receptor substrate peptide <br />
**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />
**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />
**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />
**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />
 +
**[[6bnt]] – hAP-2 C-terminal + insulin receptor substrate peptide <br />
*AP-α2 + AP-σ
*AP-α2 + AP-σ
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**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
 +
 +
*AP-β-1 + AP-γ-1 + AP-μ-1 + AP-σ-3
 +
 +
**[[6dff]], [[6d84]], [[6d83]], [[6cri]], [[6cm9]] – hAPβ-1 + APμ-1 + APσ-3 + ARF1 + tetherin-NEF – Cryo EM <br />
*AP-γ + AP-β + AP-μ + AP-σ
*AP-γ + AP-β + AP-μ + AP-σ

Revision as of 08:57, 28 February 2019

Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry 2vgl)

Drag the structure with the mouse to rotate

3D structures of adaptin

Updated on 28-February-2019

References

  1. ↑ 1.0 1.1 Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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