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6c55
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3== | |
| - | + | <StructureSection load='6c55' size='340' side='right' caption='[[6c55]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c55]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C55 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EKA:[cyclohexyl(hydroxy)amino](oxo)acetic+acid'>EKA</scene>, <scene name='pdbligand=EKD:(cyclohexylamino)(oxo)acetic+acid'>EKD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c55 OCA], [http://pdbe.org/6c55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c55 RCSB], [http://www.ebi.ac.uk/pdbsum/6c55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c55 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ILVC_STAAB ILVC_STAAB]] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ketol-acid reductoisomerase]] | ||
| + | [[Category: Guddat, L W]] | ||
| + | [[Category: Kandale, A]] | ||
| + | [[Category: McGeary, R P]] | ||
| + | [[Category: Patel, K M]] | ||
| + | [[Category: Schenk, G]] | ||
| + | [[Category: Schmbri, M]] | ||
| + | [[Category: You, L]] | ||
| + | [[Category: Zheng, S]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 12:03, 16 January 2019
Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3
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