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2hbh

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[[Image:2hbh.jpg|left|200px]]
[[Image:2hbh.jpg|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=XE4:1,3-CYCLOHEXANEDIOL,+4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-,+(1R,3S,5Z)'>XE4</scene>
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{{STRUCTURE_2hbh| PDB=2hbh | SCENE= }}
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|RELATEDENTRY=[[1db1|1DB1]], [[2hc4|2HC4]], [[2hcd|2HCD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hbh OCA], [http://www.ebi.ac.uk/pdbsum/2hbh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hbh RCSB]</span>
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'''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''
'''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
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[[Category: alpha helical sandwich]]
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[[Category: Alpha helical sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:05:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:10 2008''
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Revision as of 03:05, 4 May 2008

Image:2hbh.jpg

Template:STRUCTURE 2hbh

Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide


Overview

The crystal structures of vitamin D nuclear receptor (VDR) have revealed that all compounds are anchored by the same residues to the ligand binding pocket (LBP). Based on this observation, a synthetic analog with a locked side chain (21-nor-calcitriol-20(22),23-diyne) has been synthesized in order to gain in entropy energy with a predefined active side chain conformation. The crystal structure of VDR LBD bound to this locked side chain analogue while confirming the docking provides a structural basis for the activity of this compound.

About this Structure

2HBH is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

Reference

Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol., Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mourino A, Moras D, Arch Biochem Biophys. 2007 Apr 15;460(2):172-6. Epub 2007 Feb 20. PMID:17346665 Page seeded by OCA on Sun May 4 06:05:28 2008

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