2hci
From Proteopedia
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[[Image:2hci.gif|left|200px]] | [[Image:2hci.gif|left|200px]] | ||
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| - | | | + | {{STRUCTURE_2hci| PDB=2hci | SCENE= }} |
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'''Structure of Human Mip-3a Chemokine''' | '''Structure of Human Mip-3a Chemokine''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HCI is a [[Single protein]] structure | + | 2HCI is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Malik, Z A.]] | [[Category: Malik, Z A.]] | ||
[[Category: Tack, B F.]] | [[Category: Tack, B F.]] | ||
| - | [[Category: | + | [[Category: Dimer]] |
| - | [[Category: | + | [[Category: Macrophage inflammatory protein-3a]] |
| - | [[Category: | + | [[Category: Space group i4]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:25 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:07, 4 May 2008
Structure of Human Mip-3a Chemokine
Overview
The structure of the human macrophage inflammatory protein-3alpha (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals exhibit two molecules in the asymmetric unit. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the same monomeric structure as previously described for other chemokines. However, in addition to limited structural changes in the beta1-beta2 hairpin of monomer B, the electron density is fully defined for a few extra residues at the N- and C-termini of monomer A and the C-terminus of monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal and loop regions have been shown to be critical for receptor binding and signaling, this additional structural information may help in determining the basis of the CCR6 selectivity of MIP-3alpha.
About this Structure
2HCI is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of human MIP-3alpha chemokine., Malik ZA, Tack BF, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):631-4. Epub 2006 Jun 30. PMID:16820679 Page seeded by OCA on Sun May 4 06:07:25 2008
