1w3s
From Proteopedia
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| - | [[Image:1w3s.gif|left|200px]]<br /> | + | [[Image:1w3s.gif|left|200px]]<br /><applet load="1w3s" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1w3s" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1w3s, resolution 2.40Å" /> | caption="1w3s, resolution 2.40Å" /> | ||
'''THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.'''<br /> | '''THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1W3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3S OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sad]] | [[Category: sad]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:29:26 2007'' |
Revision as of 16:19, 18 December 2007
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THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.
Overview
The RecFOR pathway has been shown to be essential for DNA repair through, the process of homologous recombination in bacteria and, recently, to be, important in the recovery of stalled replication forks following UV, irradiation. RecO, along with RecR, RecF, RecQ and RecJ, is a principal, actor in this fundamental DNA repair pathway. Here we present the, three-dimensional structure of a member of the RecO family. The crystal, structure of Deinococcus radiodurans RecO (drRecO) reveals possible, binding sites for DNA and for the RecO-binding proteins within its three, discrete structural regions: an N-terminal, oligonucleotide/oligosaccharide-binding domain, a helical bundle and a, zinc-finger motif. Furthermore, drRecO was found to form a stable complex, with RecR and to bind both single- and double-stranded DNA. Mutational, analysis confirmed the existence of multiple DNA-binding sites within the, protein.
About this Structure
1W3S is a Single protein structure of sequence from Deinococcus radiodurans with ZN as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans., Leiros I, Timmins J, Hall DR, McSweeney S, EMBO J. 2005 Mar 9;24(5):906-18. Epub 2005 Feb 17. PMID:15719017
Page seeded by OCA on Tue Dec 18 18:29:26 2007
Categories: Deinococcus radiodurans | Single protein | Hall, D.R. | Leiros, I. | Leonard, G.A. | Mcsweeney, S.M. | Timmins, J. | ZN | Cys4 zinc finger | Dna repair | Ob-fold | Reco | Sad
