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6g0y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of M-21 protein complex== | |
| - | + | <StructureSection load='6g0y' size='340' side='right' caption='[[6g0y]], [[Resolution|resolution]] 2.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g0y]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c3b|4c3b]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0y OCA], [http://pdbe.org/6g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0y RCSB], [http://www.ebi.ac.uk/pdbsum/6g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA]] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref> [[http://www.uniprot.org/uniprot/PHOSP_HRSVA PHOSP_HRSVA]] Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Barr, J]] | [[Category: Barr, J]] | ||
| - | [[Category: Edwards, T | + | [[Category: Edwards, T A]] |
| + | [[Category: Antitermination]] | ||
| + | [[Category: Hrsv]] | ||
| + | [[Category: Replication]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 08:19, 14 November 2018
X-ray structure of M-21 protein complex
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