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2hdc

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[[Image:2hdc.gif|left|200px]]
[[Image:2hdc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hdc |SIZE=350|CAPTION= <scene name='initialview01'>2hdc</scene>
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The line below this paragraph, containing "STRUCTURE_2hdc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GENESIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_2hdc| PDB=2hdc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdc OCA], [http://www.ebi.ac.uk/pdbsum/2hdc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hdc RCSB]</span>
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}}
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'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''
'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''
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[[Category: Liao, X.]]
[[Category: Liao, X.]]
[[Category: Marsden, I.]]
[[Category: Marsden, I.]]
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[[Category: dyanamic]]
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[[Category: Dyanamic]]
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[[Category: genesis]]
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[[Category: Genesis]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: structure]]
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[[Category: Structure]]
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[[Category: winged helix protein]]
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[[Category: Winged helix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:08:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:45 2008''
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Revision as of 03:08, 4 May 2008

Image:2hdc.gif

Template:STRUCTURE 2hdc

STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX


Overview

Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.

About this Structure

2HDC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754 Page seeded by OCA on Sun May 4 06:08:55 2008

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