6gbp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative== | |
| - | + | <StructureSection load='6gbp' size='340' side='right' caption='[[6gbp]], [[Resolution|resolution]] 3.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gbp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbp OCA], [http://pdbe.org/6gbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbp RCSB], [http://www.ebi.ac.uk/pdbsum/6gbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbp ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baumeister, W]] | ||
| + | [[Category: Bracher, A]] | ||
| + | [[Category: Nagy, I]] | ||
| + | [[Category: Orsini, M]] | ||
| + | [[Category: Weyher-Stingl, E]] | ||
| + | [[Category: Zinzula, L]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 08:13, 10 October 2018
Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative
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