2hek

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[[Image:2hek.gif|left|200px]]
[[Image:2hek.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hek |SIZE=350|CAPTION= <scene name='initialview01'>2hek</scene>, resolution 1.997&Aring;
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The line below this paragraph, containing "STRUCTURE_2hek", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00077 HDc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1078 COG1078]</span>
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{{STRUCTURE_2hek| PDB=2hek | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hek OCA], [http://www.ebi.ac.uk/pdbsum/2hek PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hek RCSB]</span>
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}}
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'''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''
'''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''
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[[Category: Kim, S H.]]
[[Category: Kim, S H.]]
[[Category: Oganesyan, V.]]
[[Category: Oganesyan, V.]]
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[[Category: berkeley structural genomics center]]
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[[Category: Berkeley structural genomics center]]
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[[Category: bsgc]]
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[[Category: Bsgc]]
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[[Category: predominantly alpha helical protein with gdp binding site and active site being far from each other]]
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[[Category: Predominantly alpha helical protein with gdp binding site and active site being far from each other]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: unknown function]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:11:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:29:15 2008''
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Revision as of 03:11, 4 May 2008

Template:STRUCTURE 2hek

Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.


Overview

Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.

About this Structure

2HEK is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173 Page seeded by OCA on Sun May 4 06:11:41 2008

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