2hev

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[[Image:2hev.gif|left|200px]]
[[Image:2hev.gif|left|200px]]
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{{Structure
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|PDB= 2hev |SIZE=350|CAPTION= <scene name='initialview01'>2hev</scene>, resolution 2.41&Aring;
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The line below this paragraph, containing "STRUCTURE_2hev", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= TNFSF4, TXGP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2hev| PDB=2hev | SCENE= }}
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|RELATEDENTRY=[[2hew|2HEW]], [[2hey|2HEY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hev OCA], [http://www.ebi.ac.uk/pdbsum/2hev PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hev RCSB]</span>
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'''Crystal structure of the complex between OX40L and OX40'''
'''Crystal structure of the complex between OX40L and OX40'''
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[[Category: Compaan, D M.]]
[[Category: Compaan, D M.]]
[[Category: Hymowitz, S G.]]
[[Category: Hymowitz, S G.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: receptor-ligand complex]]
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[[Category: Receptor-ligand complex]]
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[[Category: tnfrsf]]
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[[Category: Tnfrsf]]
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[[Category: tnfsf]]
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[[Category: Tnfsf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:12:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:29:23 2008''
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Revision as of 03:12, 4 May 2008

Image:2hev.gif

Template:STRUCTURE 2hev

Crystal structure of the complex between OX40L and OX40


Overview

OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 A, respectively. These structures show that OX40L is an unusually small member of the tumor necrosis factor superfamily (TNFSF). The arrangement of the OX40L protomers forming the functional trimer is atypical and differs from that of other members by a 15 degrees rotation of each protomer with respect to the trimer axis, resulting in an open assembly. Site-directed changes of the interfacial residues of OX40L suggest this interface lacks a single "hot spot" and that instead, binding energy is dispersed over at least two distinct areas. These structures demonstrate the structural plasticity of TNFSF members and their interactions with receptors.

About this Structure

2HEV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30. PMID:16905106 Page seeded by OCA on Sun May 4 06:12:27 2008

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