1z21

From Proteopedia

(Difference between revisions)

Revision as of 08:57, 20 January 2021

Crystal structure of the core domain of Yersinia pestis virulence factor YopR

Structural highlights

1z21 is a 1 chain structure with sequence from "bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	yscH, lcrP ("Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[YSCH_YERPE] Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.

Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR.,Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS Protein Sci. 2005 Jun;14(6):1679-83. PMID:15930010^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS. Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR. Protein Sci. 2005 Jun;14(6):1679-83. PMID:15930010 doi:14/6/1679

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z21"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the core domain of Yersinia pestis virulence factor YopR==
-<StructureSection load='1z21' size='340' side='right' caption='[[1z21]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+<StructureSection load='1z21' size='340' side='right'caption='[[1z21]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1z21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z21 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1z21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Z21 FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yscH, lcrP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z21 OCA], [http://pdbe.org/1z21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z21 RCSB], [http://www.ebi.ac.uk/pdbsum/1z21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z21 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1z21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z21 OCA], [http://pdbe.org/1z21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z21 RCSB], [http://www.ebi.ac.uk/pdbsum/1z21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z21 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Austin, B P]]
 [[Category: Cherry, S]]

1z21

From Proteopedia

Revision as of 08:57, 20 January 2021

Crystal structure of the core domain of Yersinia pestis virulence factor YopR

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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