1ydg

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(Difference between revisions)

Revision as of 08:43, 20 January 2021

Crystal Structure of Trp repressor binding protein WrbA

Structural highlights

1ydg is a 8 chain structure with sequence from "micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	DRA0214 ("Micrococcus radiodurans" Raj et al. 1960)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[NQOR_DEIRA] It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although the biological role of WrbA remains unclear, it has been proposed to function in enhancing the stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA as a founding member of a flavodoxin-like family of proteins. Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide. The protomer structure is similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to the WrbA family. Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin-like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.

Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide.,Gorman J, Shapiro L Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gorman J, Shapiro L. Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide. Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580 doi:14/12/3004

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ydg"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Trp repressor binding protein WrbA==
-<StructureSection load='1ydg' size='340' side='right' caption='[[1ydg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='1ydg' size='340' side='right'caption='[[1ydg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ydg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YDG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ydg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YDG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YDG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRA0214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ydg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ydg OCA], [http://pdbe.org/1ydg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ydg RCSB], [http://www.ebi.ac.uk/pdbsum/1ydg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ydg ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1ydg TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ydg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ydg OCA], [http://pdbe.org/1ydg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ydg RCSB], [http://www.ebi.ac.uk/pdbsum/1ydg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ydg ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1ydg TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Micrococcus radiodurans raj et al. 1960]]
+[[Category: Large Structures]]
 [[Category: Burley, S K]]
 [[Category: Gorman, J]]

1ydg

From Proteopedia

Revision as of 08:43, 20 January 2021

Crystal Structure of Trp repressor binding protein WrbA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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