Adenylosuccinate lyase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The ASL can be divided into 3 domains. The <scene name='75/751814/Cv/6'>active site</scene> is situated between the 3 domains and contains the product AMP and and oxalate<ref>PMID:20693687</ref>. Water molecules are shown as red spheres. <scene name='75/751814/Cv/7'>Oxalate binding</scene>. | The ASL can be divided into 3 domains. The <scene name='75/751814/Cv/6'>active site</scene> is situated between the 3 domains and contains the product AMP and and oxalate<ref>PMID:20693687</ref>. Water molecules are shown as red spheres. <scene name='75/751814/Cv/7'>Oxalate binding</scene>. | ||
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| + | ==3D structures of adenylosuccinate lyase== | ||
| + | [[Adenylosuccinate lyase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[4nle]] – ASL – ''Mycobacterium smegmatis''<br /> | **[[4nle]] – ASL – ''Mycobacterium smegmatis''<br /> | ||
**[[4ffx]], [[4flc]] – hASL (mutant) – human<br /> | **[[4ffx]], [[4flc]] – hASL (mutant) – human<br /> | ||
| + | **[[5nx8]] – hnASL – human neadertal<br /> | ||
**[[5e3v]], [[4nsl]] – ASL – ''Salmonella typhimurium''<br /> | **[[5e3v]], [[4nsl]] – ASL – ''Salmonella typhimurium''<br /> | ||
**[[3gzh]], [[2pts]] – EcASL – ''Escherichia coli''<br /> | **[[3gzh]], [[2pts]] – EcASL – ''Escherichia coli''<br /> | ||
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**[[2ptq]] – EcASL (mutant) + fumarate + AMP <br /> | **[[2ptq]] – EcASL (mutant) + fumarate + AMP <br /> | ||
**[[2vd6]] – hASL + fumarate + AMP + dicarboxymethyl-AMP<br /> | **[[2vd6]] – hASL + fumarate + AMP + dicarboxymethyl-AMP<br /> | ||
| + | **[[5nx9]] – hnASL + fumarate + AMP <br /> | ||
| + | **[[5nxa]] – hnASL + fumarate + AICAR <br /> | ||
}} | }} | ||
Revision as of 07:34, 3 March 2019
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3D structures of adenylosuccinate lyase
Updated on 03-March-2019
References
- ↑ Kmoch S, Hartmannova H, Stiburkova B, Krijt J, Zikanova M, Sebesta I. Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. Hum Mol Genet. 2000 Jun 12;9(10):1501-13. PMID:10888601
- ↑ Mierzewska H, Schmidt-Sidor B, Jurkiewicz E, Bogdanska A, Kusmierska K, Stepien T. Severe encephalopathy with brain atrophy and hypomyelination due to adenylosuccinate lyase deficiency--MRI, clinical, biochemical and neuropathological findings of Polish patients. Folia Neuropathol. 2009;47(4):314-20. PMID:20054783
- ↑ Fyfe PK, Dawson A, Hutchison MT, Cameron S, Hunter WN. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):881-8. Epub 2010, Jul 9. PMID:20693687 doi:10.1107/S0907444910020081
