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Agglutinin

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== Function ==
== Function ==
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'''Agglutinin'''s (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state. '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>.
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'''Agglutinin'''s or '''galactose-inding lectin''' (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state. '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>.
== Disease ==
== Disease ==
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*<scene name='74/749490/Cv/8'>3rd poly-mannose binding site</scene>.
*<scene name='74/749490/Cv/8'>3rd poly-mannose binding site</scene>.
*<scene name='74/749490/Cv/9'>4th poly-mannose binding site</scene>.
*<scene name='74/749490/Cv/9'>4th poly-mannose binding site</scene>.
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== 3D Structures of agglutinin ==
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[[Agglutinin 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of lactoferrin ==
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== 3D Structures of agglutinin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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**[[3llz]] – MpAGG + polysaccharide <br />
**[[3llz]] – MpAGG + polysaccharide <br />
**[[1c3m]], [[1c3n]] – HtAGG + polysaccharide <br />
**[[1c3m]], [[1c3n]] – HtAGG + polysaccharide <br />
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**[[1cr7]], [[1ciw]], [[2tep]], [[1bzw]], [[2pel]] – pAGG + polysaccharide - peanut<br />
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**[[1cr7]], [[1ciw]], [[2tep]], [[1bzw]], [[2pel]], [[2dv9]], [[2dva]], [[2dvb]], [[2dvd]], [[2dvf]], [[2dvg]] – pAGG + polysaccharide - peanut<br />
**[[2x2t]] – SsAGG + polysaccharide <br />
**[[2x2t]] – SsAGG + polysaccharide <br />
**[[1jot]] – AGG + polysaccharide – osage orange<br />
**[[1jot]] – AGG + polysaccharide – osage orange<br />

Revision as of 10:57, 3 March 2019

Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code 4gk9)

Drag the structure with the mouse to rotate

3D Structures of agglutinin

Updated on 03-March-2019

References

  1. ↑ Dalla Pellegrina C, Perbellini O, Scupoli MT, Tomelleri C, Zanetti C, Zoccatelli G, Fusi M, Peruffo A, Rizzi C, Chignola R. Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):146-53. doi:, 10.1016/j.taap.2009.03.012. Epub 2009 Mar 28. PMID:19332085 doi:http://dx.doi.org/10.1016/j.taap.2009.03.012
  2. ↑ Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013 Aug 15;122(7):1114-21. doi: 10.1182/blood-2013-02-474437. Epub 2013, Jun 11. PMID:23757733 doi:http://dx.doi.org/10.1182/blood-2013-02-474437
  3. ↑ Whitley MJ, Furey W, Kollipara S, Gronenborn AM. Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity. FEBS J. 2013 May;280(9):2056-67. doi: 10.1111/febs.12229. Epub 2013 Apr 2. PMID:23480609 doi:10.1111/febs.12229

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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