2hiz

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[[Image:2hiz.jpg|left|200px]]
[[Image:2hiz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2hiz |SIZE=350|CAPTION= <scene name='initialview01'>2hiz</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2hiz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LIJ:BENZYL+[(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE'>LIJ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2hiz| PDB=2hiz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hiz OCA], [http://www.ebi.ac.uk/pdbsum/2hiz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hiz RCSB]</span>
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}}
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'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor'''
'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor'''
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[[Category: Prince, D B.]]
[[Category: Prince, D B.]]
[[Category: Tomasselli, A G.]]
[[Category: Tomasselli, A G.]]
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[[Category: protein-inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:21:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:07 2008''
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Revision as of 03:21, 4 May 2008

Template:STRUCTURE 2hiz

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor


Overview

We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.

About this Structure

2HIZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of potent inhibitors of human beta-secretase. Part 1., Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4. PMID:17046251 Page seeded by OCA on Sun May 4 06:21:11 2008

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