This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox GGC10
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Your Heading Here (maybe something like 'Structure')== | |
| - | <StructureSection load=' | + | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> |
| + | This is a default text for your page '''Sandbox GGC10'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | When eating, all your senses are functioning. The digestive system is preparing for the incoming food. After the eating process is complete, the final step is a signal in the stomach that stimulates the medula ablongada. Then, that signals the body to allow the hormone gastrin to work (hormone that inhibits the stomach to release its gastric juices). Gastric juice is converted pepsinogen into pepsin by removing some amino acids. Pepsin then will do its job by aiding to digest what have been intake. | ||
== Disease == | == Disease == | ||
| - | There many diseases associated with Human pepsin. For instance, peptic ulcers are very common. It is a condition when there is soreness in the lining of the stomach, small intestine, and the esophagus. There are 2 types of peptic ulcers which include gastric ulcers that happens inside the stomach and duodenal ulcers that occurs in the inside of the small intestine. The common cause of peptic ulcer is an infection with the bacterium Helicobacter pylori. Some symptoms can be stomach pain, nausea, and heartburn. It is recommended to see a doctor when someone is experiencing severe signs. | ||
== Relevance == | == Relevance == | ||
| - | Pepsin is considered a powerful enzyme found in the stomach of humans and other animals. It helps breakdown and digest proteins into small peptides like meat, seeds, eggs, or dairy products. It is produced by the human gastric mucosa. Pepsin is in complex with pepstatin. It is a very important enzyme, hence one of the first enzymes to be discovered. | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='75/752264/Pepstatin/1'>The region of the pepstatin molecule </scene> | ||
| - | The region of the pepstatin molecule show with the residues. Ala,Iva, and residues as well as Sta terminal are low on density. They must generate new conformations since the model can't fit | ||
| - | |||
| - | <scene name='75/752264/Active_sites/1'>View of active sites </scene> | ||
| - | A protein inhibitor forms an extended conformation with the first hydroxyl oxygen located in the active sites between carboxyl groups Asp 32 and Asp 215 | ||
| - | |||
| - | <scene name='75/752264/Residues/1'> View of residues Val 1- Leu 6, Asp 149- Val 184, and Gln 308-Ala 326 </scene> | ||
| - | The structure of Human Pepsin is similar to a serine Endoproteinase with molecular weight of 35 kd. the structure is divided into 3 domains. The main domain includes 6 stranded antiparallel beta sheet that helps as a backbone to the active site region. It is comprisedThe N-terminal is also composed of residues | ||
| + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | https://onlinelibrary.wiley.com/doi/epdf/10.1002/pro.5560040516?referrer_access_token=ZyEVxvIcTcmK5L-vwA_P2k4keas67K9QMdWULTWMo8PQPfTnSk44hq4jBFsrHa9ydjFbMYZrHWbY_9SWvlJek7YeLttGlVWslX2Nvc9rYhwoytl58c9enHGXzQqZutfC | ||
| - | https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/pepsin | ||
| - | http://gut.bmj.com/content/gutjnl/27/3/233.full.pdf | ||
| - | https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223 | ||
Revision as of 22:34, 17 September 2019
Your Heading Here (maybe something like 'Structure')
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
