User:Khadar Abdi/Sandbox1
From Proteopedia
(Difference between revisions)
(New page: ==Threonyl-tRNA Synthetase/ligase== <StructureSection load='4hwt' size='400' side='right' caption='Human Threonyl tRNA Synthetase bound to L-threoninamide' scene=''> == Function == '''Thr...) |
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<StructureSection load='4hwt' size='400' side='right' caption='Human Threonyl tRNA Synthetase bound to L-threoninamide' scene=''> | <StructureSection load='4hwt' size='400' side='right' caption='Human Threonyl tRNA Synthetase bound to L-threoninamide' scene=''> | ||
| - | == Function == | + | == Function/Mechanism == |
| - | '''Threonyl t-RNA Synthetase''' or '''Threonyl-tRNA ligase''' is class II '''Aminoacyl-tRNA synthetase''' enzymes. The main function of the enzyme is to add Threonine amino acid to tRNA | + | '''Threonyl t-RNA Synthetase''' or '''Threonyl-tRNA ligase''' or '''TARS''' is class II '''Aminoacyl-tRNA synthetase''' enzymes. These enzymes primary function are The main function of the enzyme is to add Threonine amino acid (Thr) to threonine specific tRNA (tRNA-thr) a necessity prep for the protein synthesis pathway. Below displays the overview of the Aminoacylation rxn<ref>PMID:29305884</ref> |
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| + | [[Image:TARS_protein_rxn.jpeg |left|thumb|500px| '''Overall TARS protein rxn. Substrates includes Adenosine triphosphate (ATP), Threonine (Thr) and threonine specific transfer Ribonucleic Acid (tRNA-thr).''']] | ||
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| + | TARS adds amino acid to tRNA by a two-step mechanism. First the enzyme binds to both Threonine and ATP in the catalytic domain to perform an adenylation reaction in which pyrophosphate is released as a byproduct. This is then follow up by a transferring Thr from Adenosine monophosphate molecule to 3'OH site of tRNA-thr. <ref>Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2000). ''Lehninger principles of biochemistry.'' New York: Worth Publishers.</ref> Image below demonstrates the arrow pushing occuring to generate threonine bound tRNA-thr.[[Image:TARSmechanism.jpg]] | ||
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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== References == | == References == | ||
| + | <references/> | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
| - | == References == | ||
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| - | <references/> | ||
Revision as of 18:36, 28 April 2018
Threonyl-tRNA Synthetase/ligase
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