Sandbox Reserved 1452

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Put basic info about uricase here
Put basic info about uricase here
== Function ==
== Function ==
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It is an enzyme that converts uric acid to allantoin. Allantoin is much more soluble than uric acid, and passes harmlessly from the body. Unfortunately, during evolution, humans have lost the ability to produce uricase (also called urate oxidase).
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It is an enzyme that converts uric acid to allantoin. Allantoin is much more soluble than uric acid, and passes harmlessly from the body. Unfortunately, during evolution, humans have lost the ability to produce uricase. The detailed mechanism consists or this copper binding enzyme catalyzing the oxidation or uric acid to .5-hydroxyisourate and hydrogen peroxide followed by the hydrolysis and decarboxylation leading to the formation of the desired product, allantoin. Allantoin is significantly more water soluble than uric acid and easily excreted in urine.
== Disease ==
== Disease ==
If there is some damage to uricase or if it is absent in the body, it may be detrimental. Without functioning uricase, there will be an excess amount of insoluble uric acid in the body which leads to a disease called gout. Gout is a form of inflammatory arthritis that develops in people who have high levels of uric acid in the blood. The acid forms needle-like crystals in joints and causes sudden, severe episodes of pain, redness, and swelling.
If there is some damage to uricase or if it is absent in the body, it may be detrimental. Without functioning uricase, there will be an excess amount of insoluble uric acid in the body which leads to a disease called gout. Gout is a form of inflammatory arthritis that develops in people who have high levels of uric acid in the blood. The acid forms needle-like crystals in joints and causes sudden, severe episodes of pain, redness, and swelling.
Uric acid is a waste material made by the breakdown of purines. Purines are found in foods high in protein. Gout occurs when uric acid accumulates which happens when there is more intake of uric acid than excreted uric acid. This leads to acute gout. The immune system recognizes it as a foreign product and attacks it. This will then lead to inflammation. The joint could be damaged or there could be bone erosion when the join is attacked.
Uric acid is a waste material made by the breakdown of purines. Purines are found in foods high in protein. Gout occurs when uric acid accumulates which happens when there is more intake of uric acid than excreted uric acid. This leads to acute gout. The immune system recognizes it as a foreign product and attacks it. This will then lead to inflammation. The joint could be damaged or there could be bone erosion when the join is attacked.
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== Cure ==
There are many natural treatment options which include a decrease of purine intake, exercise, decrease smoking and alcohol intake, use of cherry juice (eliminate excess uric acid in blood). Another type of treatment available is gout therapy and medication. Pegloticase is a porcine uricase which is approved by the FDA for treatment of patients with gout. It must be administered by intravenous infusion every two weeks. Corticosteroids can also be taken by mouth or injected into an inflamed joint to relieve the pain and swelling of an acute gout attack. Corticosteroids and adrenocorticotropic hormones usually start working within 24 hours after you begin taking them.
There are many natural treatment options which include a decrease of purine intake, exercise, decrease smoking and alcohol intake, use of cherry juice (eliminate excess uric acid in blood). Another type of treatment available is gout therapy and medication. Pegloticase is a porcine uricase which is approved by the FDA for treatment of patients with gout. It must be administered by intravenous infusion every two weeks. Corticosteroids can also be taken by mouth or injected into an inflamed joint to relieve the pain and swelling of an acute gout attack. Corticosteroids and adrenocorticotropic hormones usually start working within 24 hours after you begin taking them.
== Relevance ==
== Relevance ==

Revision as of 21:16, 28 April 2018

This Sandbox is Reserved from Jan 22 through May 22, 2018 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, Missouri, USA. This reservation includes Sandbox Reserved 1446 through Sandbox Reserved 1455.
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Uricase

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