2hlb

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[[Image:2hlb.gif|left|200px]]
[[Image:2hlb.gif|left|200px]]
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{{Structure
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|PDB= 2hlb |SIZE=350|CAPTION= <scene name='initialview01'>2hlb</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2hlb", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|GENE= GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2hlb| PDB=2hlb | SCENE= }}
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|RELATEDENTRY=[[1y3a|1Y3A]], [[1as3|1AS3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlb OCA], [http://www.ebi.ac.uk/pdbsum/2hlb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hlb RCSB]</span>
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'''A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity'''
'''A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity'''
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[[Category: Siderovski, D P.]]
[[Category: Siderovski, D P.]]
[[Category: Watts, V J.]]
[[Category: Watts, V J.]]
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[[Category: protein:peptide complex]]
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[[Category: Protein:peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:25:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:53 2008''
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Revision as of 03:25, 4 May 2008

Image:2hlb.gif

Template:STRUCTURE 2hlb

A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity


Overview

Heterotrimeric G proteins are molecular switches that relay information intracellularly in response to various extracellular signals. How ligand-activated G protein-coupled receptors act at a distance to exert exchange activity on the Galpha nucleotide binding pocket is poorly understood. Here we describe the synergistic action of two peptides: one from the third intracellular loop of the D2 dopamine receptor (D2N), and a second, Galpha.GDP-binding peptide (KB-752) that mimics the proposed role of Gbetagamma in receptor-promoted nucleotide exchange. The structure of both peptides in complex with Galpha(i1) suggests that conformational changes in the beta3/alpha2 loop and beta6 strand act in concert for efficient nucleotide exchange. Two key residues in the alpha4 helix were found to define a receptor/Galpha(i) coupling specificity determinant.

About this Structure

2HLB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity., Johnston CA, Siderovski DP, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214 Page seeded by OCA on Sun May 4 06:25:26 2008

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