2hn7

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[[Image:2hn7.gif|left|200px]]
[[Image:2hn7.gif|left|200px]]
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{{Structure
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|PDB= 2hn7 |SIZE=350|CAPTION= <scene name='initialview01'>2hn7</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2hn7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2hn7| PDB=2hn7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hn7 OCA], [http://www.ebi.ac.uk/pdbsum/2hn7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hn7 RCSB]</span>
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}}
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'''HLA-A*1101 in complex with HBV peptide homologue'''
'''HLA-A*1101 in complex with HBV peptide homologue'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Blicher, T.]]
[[Category: Blicher, T.]]
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[[Category: hbv]]
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[[Category: Hbv]]
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[[Category: hepatitis b virus]]
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[[Category: Hepatitis b virus]]
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[[Category: hla]]
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[[Category: Hla]]
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[[Category: human leukocyte antigen]]
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[[Category: Human leukocyte antigen]]
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[[Category: immunoglobulin family]]
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[[Category: Immunoglobulin family]]
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[[Category: major histocompatibility complex class i]]
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[[Category: Major histocompatibility complex class i]]
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[[Category: mhc-i]]
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[[Category: Mhc-i]]
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[[Category: peptide-mhc-complex]]
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[[Category: Peptide-mhc-complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:28:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:37 2008''
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Revision as of 03:28, 4 May 2008

Image:2hn7.gif

Template:STRUCTURE 2hn7

HLA-A*1101 in complex with HBV peptide homologue


Contents

Overview

A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2HN7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892 Page seeded by OCA on Sun May 4 06:28:49 2008

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OCA

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