5xuo
From Proteopedia
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<StructureSection load='5xuo' size='340' side='right' caption='[[5xuo]], [[Resolution|resolution]] 2.59Å' scene=''> | <StructureSection load='5xuo' size='340' side='right' caption='[[5xuo]], [[Resolution|resolution]] 2.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5xuo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XUO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5xuo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XUO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xuo OCA], [http://pdbe.org/5xuo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xuo RCSB], [http://www.ebi.ac.uk/pdbsum/5xuo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xuo ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pks13, Rv3800c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xuo OCA], [http://pdbe.org/5xuo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xuo RCSB], [http://www.ebi.ac.uk/pdbsum/5xuo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xuo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Type I polyketide synthase 13 (Pks13) is involved in the final step of the biosynthesis of mycolic acid in Mycobacterium tuberculosis. Recent articles have reported that Pks13 is an essential enzyme in the mycolic acid biosynthesis pathway, and it has been deeply studied as a drug target in Tuberculosis. We report a high-resolution structure of the acyltransferase (AT) domain of Pks13 at 2.59 A resolution. Structural comparison with the full-length AT domain (PDB code, 3TZW, and 3TZZ) reveals a different orientation of the C-terminal helix and rearrangement of some conserved residues. | ||
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| + | Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.,Yu M, Dou C, Gu Y, Cheng W PeerJ. 2018 May 7;6:e4728. doi: 10.7717/peerj.4728. eCollection 2018. PMID:29761048<ref>PMID:29761048</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5xuo" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Myctu]] | ||
[[Category: Cheng, W]] | [[Category: Cheng, W]] | ||
[[Category: Dou, C]] | [[Category: Dou, C]] | ||
Revision as of 05:50, 30 May 2018
Pks13 AT domain fragment from Mycobacterium tuberculosis
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Categories: Myctu | Cheng, W | Dou, C | Gu, Y J | Yu, M J | Fragment | Transferase
